Journal article
Biophysical basis of the linear electrical receptive fields of retinal ganglion cells
Timothy B Esler, Matias Maturana, Robert R Kerr, David B Grayden, Anthony N Burkitt, Hamish Meffin
JOURNAL OF NEURAL ENGINEERING | IOP PUBLISHING LTD | Published : 2018
Abstract
UNLABELLED: Responses of retinal ganglion cells to direct electrical stimulation have been shown experimentally to be well described by linear-nonlinear models. These models rely on the simplifying assumption that retinal ganglion cell responses to stimulation with an array of electrodes are driven by a simple linear weighted sum of stimulus current amplitudes from each electrode, known as the 'electrical receptive field'. OBJECTIVE: This paper aims to demonstrate the biophysical basis of the linear-nonlinear model and the electrical receptive field to facilitate the development of improved stimulation strategies for retinal implants. APPROACH: We compare the linear-nonlinear model of subret..
View full abstractRelated Projects (3)
Grants
Awarded by Australian Research Council Centre of Excellence for Integrative Brain Function
Awarded by Australian Research Council's Discovery Projects funding scheme
Awarded by Australian National Health and Medical Research Councils Project Grant funding scheme (NHMRC)
Funding Acknowledgements
TE was supported by an Australian Government Research Training Program Stipend Scholarship from the Australian Government and The University of Melbourne, and the Gowrie Scholarship Fund of the Australian National University. RRK acknowledges the support of Seer Medical, who provided support in the form of a salary for part of the period during which this research was completed, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. HM acknowledges funding from the Australian Research Council Centre of Excellence for Integrative Brain Function (project number CE140100007). ANB acknowledges the support of the Australian Research Council's Discovery Projects funding scheme (project number DP140104533). DBG, HM, and ANB acknowledge the support of the Australian National Health and Medical Research Councils Project Grant funding scheme (NHMRC Grant APP1106390). Ewan Nurse, Philippa Karoly, Dr Jessica Opie, Wei Tong are thanked for providing feedback and discussion.