Journal article
Follow-up study of hpv58 variants in women with incident hpv58 infection from a colombian cohort
M Molano, O Buitrago, P Moreno-Acosta, SM Garland, N Morales, A Huertas, T Martinez, O Gamboa, SN Tabrizi, A Cornall, N Muñoz
Oncology Letters | SPANDIDOS PUBL LTD | Published : 2018
DOI: 10.3892/ol.2018.8928
Abstract
Certain variants of human papillomavirus (HPV) type 58 are associated with an increased risk of high grade squamous intraepithelial lesions and cervical cancer. However, little is known about the persistence of HPV58 E6/E7 variants in women with incident HPV58 infections. The aim of the present study was to evaluate the presence and persistence of HPV58 E6/E7 variants in 71 women with incident HPV58 infection throughout their follow-up. These women belonged to a cohort examined in a longitudinal study of 1,610 Colombian women, who were HPV-negative and had normal baseline cytology. E6/E7 DNA regions of HPV58-positive samples were amplified and sequenced using automated direct sequencing. A t..
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Awarded by National Cancer Institute
Funding Acknowledgements
The authors would like to thank the National Cancer Institute HPV study group: Dr Mauricio Gonzalez, Dr Natasha Ortiz, Dr Gustavo Hernandez, Dr Oscar Gamboa, Dr Raul H Murillo, Dr Joaquin Luna, Dr Hector Posso, Dr Margarita Ronderos, Dr Gilberto Martinez, Dr Edmundo Mora, Dr Gonzalo Perez, Dr Jose Maria Fuentes, Dr Constanza Gomez, Dr Eva Klaus, Mrs Constanza Camargo, Mrs Cecilia Tobon, Mrs Teodolinda Palacio, Dr Carolina Suarez, Mrs Claudia Molina and Mr Alex Torres. The present study was supported by the National Cancer Institute, Bogota, Colombia (DNP grant no. 41030310-30).