Journal article

Novel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor

Frederique MC Boonstra, Thushara Perera, Gustavo Noffs, Cassandra Marotta, Adam P Vogel, Andrew H Evans, Helmut Butzkueven, Bradford A Moffat, Anneke van der Walt, Scott C Kolbe



Introduction: Tremor of the upper limbs is a disabling symptom that is present during several neurological disorders and is currently without treatment. Functional MRI (fMRI) is an essential tool to investigate the pathophysiology of tremor and aid the development of treatment options. However, no adequately or standardized protocols for fMRI exists at present. Here we present a novel, online available fMRI task that could be used to assess the in vivo pathology of tremor. Objective: This study aims to validate the tremor-evoking potential of the fMRI task in a small group of tremor patients outside the scanner and assess the reproducibility of the fMRI task related activation in healthy con..

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Awarded by NHMRC Project Grant

Awarded by National Health and Medical Research Council, Australia (Career Development Fellowship)

Awarded by NHRMC Practitioner Fellowship

Awarded by NHMRC Early Career Fellowship

Funding Acknowledgements

This project was funded by an NHMRC Project Grant (1085461 CIA AvdW). Bionics Institute receives Operational Infrastructure Support from the Victorian Government. AV receives funding from the National Health and Medical Research Council, Australia (Career Development Fellowship ID 1082910), received funding from the Alexander von Humboldt Foundation and receives institutional support from The University of Melbourne. AE has received honoraria from Novartis for giving presentations and providing consultancy services. He has participated in scientific advisory board meetings for Novartis, UCB Pharma, Allergan, and Boehringer Ingelheim. He has received conference travel support from Boehringer Ingelheim. HB is supported by an NHRMC Practitioner Fellowship 1080518. BM receives a fellowship from the National Institutes of Health. AvdW is supported by an NHMRC Early Career Fellowship (1123330). SK receives grant income from the National Health and Medical Research Council of Australia and has received honoraria from Novartis.