Journal article
Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging
MP Vasconcelos-Moreno, GR Fries, C Gubert, BTMQ Dos Santos, A Fijtman, J Sartori, P Ferrari, LK Grun, MM Parisi, FTCR Guma, FM Barbé-Tuana, F Kapczinski, AR Rosa, LN Yatham, M Kauer-Sant'Anna
International Journal of Neuropsychopharmacology | OXFORD UNIV PRESS | Published : 2017
DOI: 10.1093/ijnp/pyx001
Abstract
Background: Growing evidence supports the existence of neurobiological trait abnormalities in individuals at genetic risk for bipolar disorder. The aim of this study was to examine potential differences in brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with bipolar disorder, their siblings, and healthy controls. Methods: Thirty-six patients with bipolar disorder type I, 39 siblings, and 44 healthy controls were assessed. Serum levels of brain-derived neurotrophic factor, interleukin-6, interleukin-10, tumor necrosis factor-α, C-C motif chemokine 11, C-C motif chemokine 24, and 3-nitrotyrosine were measured, as were the activities ..
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Funding Acknowledgements
This work was supported by grants from the National Science and Technology Institute for Translational Medicine (INCT-TM), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), and Fundo de Incentivo a Pesquisa - Hospital de Clinicas de Porto Alegre (FIPE-HCPA).