Journal article
TBARS and BDNF levels in newborns exposed to crack/cocaine during pregnancy: A comparative study
V Mardini, LA Rohde, KM Ceresér, CM Gubert, EG da Silva, F Xavier, R Parcianello, LM Röhsig, F Pechansky, CM Szobot
Revista Brasileira De Psiquiatria | ASSOC BRASILEIRA PSIQUIATRIA | Published : 2017
Abstract
Objectives: To compare levels of a marker of lipid peroxidation (thiobarbituric acid reactive substances, TBARS) and brain-derived neurotrophic factor (BDNF) in umbilical cord blood (UCB) between newborns exposed to crack/cocaine in utero (exposed newborns [EN], n=57) and non-exposed newborns (NEN, n=99), as well as in maternal peripheral blood at delivery. Methods: This was a cross-sectional study. Potential confounders, including perinatal parameters, psychopathology, and use of other substances, were assessed. Results: After adjusting for potential confounders, adjusted mean BDNF was significantly higher in EN (3.86 ng/mL, 95% confidence interval [95%CI] 2.29-5.43) than in NEN (0.85 ng/mL..
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Funding Acknowledgements
This study was funded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS) and Fundo de Incentivo a Pesquisa e Eventos (FIPE) of the Hospital de Clinicas de Porto Alegre (HCPA). All provided financial support for study development, laboratory testing, and all other expenses.