Journal article
Peripheral adenosine levels in euthymic patients with bipolar disorder
C Gubert, CE Jacintho Moritz, MP Vasconcelos-Moreno, BTM Quadros dos Santos, J Sartori, A Fijtman, M Kauer-Sant'Anna, F Kapczinski, AMO Battastini, PVDS Magalhães
Psychiatry Research | ELSEVIER IRELAND LTD | Published : 2016
Abstract
Recent evidence points to the involvement of the purinergic signaling in the pathophysiology of bipolar disorder. The aim of this study was to assess the serum levels of adenosine and to evaluate its relation to functioning in 24 euthymic patients with bipolar disorder type I and in 25 matched healthy controls. Subjects were evaluated using the functioning assessment short test. Serum purine levels were measured by high pressure liquid chromatography. Our results show a decrease in serum adenosine levels in bipolar disorder patients compared with controls (t= −4.8, df= 43.96, p<0.001). Moreover, a significant negative correlation was found between patient adenosine levels and depression scal..
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Funding Acknowledgements
This work was supported by Fundo de Incentivo a Pesquisa-Hospital de Clinicas de Porto Alegre (FIPE-HCPA) and CNPq: National Science and Technology Institute for Translational Medicine and Research Fellowship. The funding agencies did not have any role in study design, data collection and analysis, the decision to publish, or manuscript preparation. C. Gubert was supported by a doctoral scholarship from CAPES and CNPq.