Journal article
Role of P2X7 Receptor in an Animal Model of Mania Induced by D-Amphetamine
C Gubert, GR Fries, B Pfaffenseller, P Ferrari, R Coutinho-Silva, FB Morrone, F Kapczinski, AMO Battastini
Molecular Neurobiology | SPRINGER | Published : 2016
Abstract
The objective of this study was to explore the association between the P2X7 purinergic receptor (P2X7R) and neuroinflammation using a preclinical model of acute bipolar mania. We analyzed the modulatory effects of P2X7R agonist (3′-O-(4-benzoyl)benzoyl-adenosine 5′-triphosphate, BzATP) and antagonists (brilliant blue, BBG and 3-[[5-(2,3 dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride, A438079) on assessments related to behavior (locomotor activity), neuroinflammation (interleukin-1 beta, IL-1β; tumor necrosis factor alpha, TNF-α; and interleukin- 6, IL-6), oxidative stress (thiobarbituric acid reactive substances, TBARS) and neuroplasticity (brain-derived neurotrophic factor, ..
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Funding Acknowledgements
CG, GRF, and PF are recipients of scholarships from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq). BP is a scholarship recipient from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES). This study was supported by the National Science and Technology Institute for Translational Medicine, funded by CNPq and by Fundo de Incentivo a Pesquisa do Hospital de Clinicas de Porto Alegre (FIPE-HCPA).