Reelin Haploinsufficiency and Late-Adolescent Corticosterone Treatment Induce Long-Lasting and Female-Specific Molecular Changes in the Dorsal Hippocampus
Anna Schroeder, Maarten van den Buuse, Rachel A Hill
BRAIN SCIENCES | MDPI | Published : 2018
Reelin depletion and stress seem to affect similar pathways including GABAergic and glutamatergic signaling and both are implicated in psychiatric disorders in late adolescence/early adulthood. The interaction between reelin depletion and stress, however, remains unclear. To investigate this, male and female heterozygous reelin mice (HRM) and wildtype (WT) controls were treated with the stress hormone, corticosterone (CORT), during late adolescence to simulate chronic stress. Glucocorticoid receptors (GR), N-methyl-d-aspartate receptor (NMDAr) subunits, glutamic acid decarboxylase (GAD67) and parvalbumin (PV) were measured in the hippocampus and the prefrontal cortex (PFC) in adulthood. Whil..View full abstract
Related Projects (1)
This research was undertaken at The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, supported by project grant funding from the National Health and Medical Research Council of Australia (NHMRC). A.S. was in receipt of a Melbourne International Research Scholarship as well as a Melbourne International Fee Remission Scholarship. M.v.d.B. was supported by a NHMRC senior research fellowship. R.A.H. was supported by a NHMRC Career Development Fellowship. This funding body had no involvement in the study design, the collection, analysis and interpretation of data, or the writing of the paper and the decision to submit it for publication.