Myoprotective potential of creatine is greater than whey protein after chemically-induced damage in rat skeletal muscle

Abstract

The myoprotective effects of creatine monohydrate (CR) and whey protein (WP) are equivocal, with the use of proxymeasures ofmuscle damagemaking interpretation of their effectiveness limited. The purpose of the study was to determine the effects of CR and WP supplementation on muscle damage and recovery following controlled, chemically-induced muscle damage. Degeneration of the extensor digitorum longus (EDL) muscle was induced by bupivacaine in rats supplemented with either CR, WP, or standard rat chow (CON). At day 7 and 14 post-myotoxic injury, injured EDL muscles were surgically removed and tested for isometric contractile properties, followed by the contralateral, non-injured EDL muscle...