Journal article
Evidence that calcium entry into calcium-transporting dental enamel cells is regulated by cholecystokinin, acetylcholine and ATP
MK Nurbaeva, M Eckstein, A Devotta, JP Saint-Jeannet, DI Yule, MJ Hubbard, RS Lacruz
Frontiers in Physiology | FRONTIERS MEDIA SA | Published : 2018
Open access
Abstract
Dental enamel is formed by specialized epithelial cells which handle large quantities of Ca2+ while producing the most highly mineralized tissue. However, the mechanisms used by enamel cells to handle bulk Ca2+ safely remain unclear. Our previous work contradicted the dogma that Ca2+ is ferried through the cytosol of Ca2+-transporting cells and instead suggested an organelle-based route across enamel cells. This new paradigm involves endoplasmic reticulum (ER)-associated Ca2+ stores and their concomitant refilling by store-operated Ca2+ entry (SOCE) mediated by Ca2+ release activated Ca2+ (CRAC) channels. Given that Ca2+ handling is maximal during the enamel-mineralization stage (maturation)..
View full abstractGrants
Funding Acknowledgements
This work was funded by National Institute of Dental and Craniofacial Research (NIH/NIDCR) awards to RL (DE022799 and DE025639), DY (DE014756), and J-PS-J (DE25806 and DE25468). MH gratefully acknowledges the Faculty of Medicine, Dentistry and Health Sciences at The University of Melbourne for ongoing support.