Journal article
Fabrication and in vitro characterization of electrochemically compacted collagen/sulfated xylorhamnoglycuronan matrix for wound healing applications
L Kang, X Liu, Z Yue, Z Chen, C Baker, PC Winberg, GG Wallace
Polymers | MDPI | Published : 2018
Abstract
Skin autografts are in great demand due to injuries and disease, but there are challenges using live tissue sources, and synthetic tissue is still in its infancy. In this study, an electrocompaction method was applied to fabricate the densely packed and highly ordered collagen/sulfated xylorhamnoglycuronan (SXRGlu) scaffold which closely mimicked the major structure and components in natural skin tissue. The fabricated electrocompacted collagen/SXRGlu matrices (ECLCU) were characterized in terms of micromorphology, mechanical property, water uptake ability and degradability. The viability, proliferation and morphology of human dermal fibroblasts (HDFs) cells on the fabricated matrices were a..
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Awarded by Australian National Fabrication Facility
Funding Acknowledgements
The authors wish to acknowledge funding from the Australian Research Council (ARC) Centre of Excellence Scheme (CE140100012), the use of facilities at the University of Wollongong Electron Microscopy Centre, supporting from the Australian National Fabrication Facility (ANFF)-Materials Node, and the funding from the Bauer grant. Xiao Liu would like to acknowledge the support of ARC Industrial Transformation Training Centre in Additive Biomanufacturing (ARC IC160100026).