Long-Term Outcomes of Hypertrophic Cardiomyopathy Diagnosed During Childhood: Results From a National Population-Based Study
Peta MA Alexander, Alan W Nugent, Piers EF Daubeney, Katherine J Lee, Lynn A Sleeper, Tibor Schuster, Christian Turner, Andrew M Davis, Chris Semsarian, Steven D Colan, Terry Robertson, James Ramsay, Robert Justo, Gary F Sholler, Ingrid King, Robert G Weintraub
CIRCULATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
BACKGROUND: Late survival and symptomatic status of children with hypertrophic cardiomyopathy have not been well defined. We examined long-term outcomes for pediatric hypertrophic cardiomyopathy. METHODS: The National Australian Childhood Cardiomyopathy Study is a longitudinal population-based cohort study of children (0-10 years of age) diagnosed with cardiomyopathy between 1987 and 1996. The primary study end point was time to death or cardiac transplantation. RESULTS: There were 80 patients with hypertrophic cardiomyopathy, with a median age at diagnosis of 0.48 (interquartile range, 0.1, 2.5) years. Freedom from death/transplantation was 86% (95% confidence interval [CI], 77.0-92.0) 1 ye..View full abstract
Awarded by Royal Children's Hospital Research Foundation, Melbourne, Australia
Awarded by National Heart Foundation of Australia, Sydney
Awarded by National Health and Medical Research Committee Practitioner Fellowship, Canberra, Australia
This study was supported by grant 98001 from The Royal Children's Hospital Research Foundation, Melbourne, Australia; grants G 98M 0159, G 04M 1586, G 05M 2151, and G 07M 3180 from the National Heart Foundation of Australia, Sydney; an NACCS grant from the Australia and New Zealand Children's Heart Research Center, Melbourne, Australia; and an NACCS grant from Heartkids Australia, Sydney. Dr Daubeney is supported by the Biomedical Research Unit at the Royal Brompton Hospital, London, United Kingdom. Dr Semsarian is the recipient of a National Health and Medical Research Committee Practitioner Fellowship (1059156), Canberra, Australia.