Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study.

Marianna Parlato; François Philippart; Alexandra Rouquette; Virginie Moucadel; Virginie Puchois; Sophie Blein; Jean-Pierre Bedos; Jean-Luc Diehl; Olfa Hamzaoui; Djillali Annane; Didier Journois; Myriam Ben Boutieb; Laurent Estève; Catherine Fitting; Jean-Marc Treluyer; Alexandre Pachot; Minou Adib-Conquy; Jean-Marc Cavaillon; Benoît Misset; Captain Study Group

Journal article

Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study.

Marianna Parlato, François Philippart, Alexandra Rouquette, Virginie Moucadel, Virginie Puchois, Sophie Blein, Jean-Pierre Bedos, Jean-Luc Diehl, Olfa Hamzaoui, Djillali Annane, Didier Journois, Myriam Ben Boutieb, Laurent Estève, Catherine Fitting, Jean-Marc Treluyer, Alexandre Pachot, Minou Adib-Conquy, Jean-Marc Cavaillon, Benoît Misset, undefined Captain Study Group

Intensive Care Med | Published : 2018

DOI: 10.1007/s00134-018-5228-3

Abstract

PURPOSE: Sepsis and non-septic systemic inflammatory response syndrome (SIRS) are the same syndromes, differing by their cause, sepsis being secondary to microbial infection. Microbiological tests are not enough to detect infection early. While more than 50 biomarkers have been proposed to detect infection, none have been repeatedly validated. AIM: To assess the accuracy of circulating biomarkers to discriminate between sepsis and non-septic SIRS. METHODS: The CAPTAIN study was a prospective observational multicenter cohort of 279 ICU patients with hypo- or hyperthermia and criteria of SIRS, included at the time the attending physician considered antimicrobial therapy. Investigators collecte..

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