Journal article

Characteristics of circular RNA expression in lung tissues from mice with hypoxia-induced pulmonary hypertension

Jian Wang, Meng-Chan Zhu, Bill Kalionis, Jun-Zhen Wu, Lin-Lin Wang, Hai-Yan Ge, Cui-Cui Chen, Xiao-Dan Tang, Yuan-Lin Song, Hong He, Shi-Jin Xia

International Journal of Molecular Medicine | SPANDIDOS PUBL LTD | Published : 2018

Abstract

Pulmonary hypertension (PH) is a life‑threatening lung disease, characterized by an increase in pulmonary arterial pressure caused by vasoconstriction and vascular remodeling. The pathogenesis of PH is not fully understood, and there is a lack of potential biomarkers for the diagnosis and treatment of patients with PH. Non‑coding RNAs with a characteristic covalently closed loop structure, termed circular RNAs (circRNAs), are present in a number of pulmonary diseases. To the best of our knowledge, the present study is the first to use microarray analysis to determine the expression profile of circRNAs in lung tissues from mice with hypoxia‑induced PH. In total, 23 significantly upregulated a..

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Grants

Awarded by State Key Basic Research Program Project


Awarded by National Natural Science Foundation of China


Awarded by Shanghai Science and Technology Committee


Awarded by Shanghai Municipal Commission of Health and Family Planning



Funding Acknowledgements

The study was supported by the State Key Basic Research Program Project (grant no. 2015CB553404), the National Natural Science Foundation of China (grant nos. 81770055, 81500026, 81570028 and 81600056), the Key Grant (grant nos. 81630001 and 81490533), the National Natural Science Foundation of China for Young Researcher (grant no. 81600056), the Shanghai Science and Technology Committee Grant (grant nos. 15DZ1930600, 15DZ193060 and 16ZR1405700) and the Shanghai Municipal Commission of Health and Family Planning (grant no. 201540370).