Journal article

Paclitaxel-Loaded Self-Assembled Lipid Nanoparticles as Targeted Drug Delivery Systems for the Treatment of Aggressive Ovarian Cancer

Jiali Zhai, Rodney B Luwor, Nuzhat Ahmed, Ruth Escalona, Fiona H Tan, Celesta Fong, Julian Ratcliffe, Judith A Scoble, Calum J Drummond, Nhiem Tran



Chemotherapy using cytotoxic agents, such as paclitaxel (PTX), is one of the most effective treatments for advanced ovarian cancer. However, due to nonspecific targeting of the drug and the presence of toxic solvents required for dissolving PTX prior to injection, there are several serious side effects associated with this treatment. In this study, we explored self-assembled lipid-based nanoparticles as PTX carriers, which were able to improve its antitumour efficacy against ovarian cancer. The nanoparticles were also functionalized with epidermal growth factor receptor (EGFR) antibody fragments to explore the benefit of tumor active targeting. The formulated bicontinuous cubic- and sponge-p..

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Funding Acknowledgements

The authors thank Dr. Tim Adams from CSIRO for his kind discussion of the project. This research includes work undertaken on the SAXS/WAXS beamline at Australian Synchrotron, Victoria, Australia. The authors also thank Drs. Adrian Hawley, Stephen Mudie, and Nigel Kirby for their assistance with the SAXS experiments. They thank Paul Morrison for his help with high-performance liquid chromatography experiment. The authors acknowledge the facilities and the scientific and technical assistance of the RMIT University's MicroNano Research Facility. The authors acknowledge the Enabling Capability Development Fund scheme at RMIT University and a CASS Foundation Science/Medicine Grant for the financial support. N.T. is a recipient of the RMIT Vice-Chancellor's Research Fellowship.