Age at first birth in women is genetically associated with increased risk of schizophrenia

G Ni; J Gratten; NR Wray; SH Lee; S Ripke; BM Neale; A Corvin; JTR Walters; KH Farh; PA Holmans; P Lee; B Bulik-Sullivan; DA Collier; H Huang; TH Pers; I Agartz; E Agerbo; M Albus; M Alexander; F Amin; SA Bacanu; M Begemann; RA Belliveau; J Bene; SE Bergen; E Bevilacqua; TB Bigdeli; DW Black; R Bruggeman; NG Buccola; RL Buckner; W Byerley; W Cahn; G Cai; D Campion; RM Cantor; VJ Carr; N Carrera; SV Catts; KD Chambert; RCK Chan; RYL Chen; EYH Chen; W Cheng; EFC Cheung; SA Chong; CR Cloninger; D Cohen; N Cohen; P Cormican; N Craddock; JJ Crowley; D Curtis; M Davidson; KL Davis; F Degenhardt; J Del Favero; D Demontis; D Dikeos; T Dinan; S Djurovic; G Donohoe; E Drapeau; J Duan; F Dudbridge; N Durmishi; P Eichhammer; J Eriksson; V Escott-Price; L Essioux; AH Fanous; MS Farrell; J Frank; L Franke; R Freedman; NB Freimer; M Friedl; JI Friedman; M Fromer; G Genovese; L Georgieva; I Giegling; P Giusti-Rodríguez; S Godard; JI Goldstein; V Golimbet; S Gopal; LD Haan; C Hammer; ML Hamshere; M Hansen; T Hansen; V Haroutunian; AM Hartmann; FA Henskens; S Herms; JN Hirschhorn; P Hoffmann; A Hofman; MV Hollegaard

Journal article

Age at first birth in women is genetically associated with increased risk of schizophrenia

G Ni, J Gratten, NR Wray, SH Lee, S Ripke, BM Neale, A Corvin, JTR Walters, KH Farh, PA Holmans, P Lee, B Bulik-Sullivan, DA Collier, H Huang, TH Pers, I Agartz, E Agerbo, M Albus, M Alexander, F Amin Show all

Scientific Reports | NATURE PORTFOLIO | Published : 2018

DOI: 10.1038/s41598-018-28160-z

Download PDF

Abstract

Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AF..

View full abstract

University of Melbourne Researchers

Eric Yu Hai Chen Author

Christos Pantelis Author

Grants

Awarded by Australian Research Council

Funding Acknowledgements

This research is supported by the Australian National Health and Medical Research Council (1080157, 1087889, 1103418, 1127440), and the Australian Research Council (DP160102126, FT160100229). This research has been conducted using the UK Biobank Resource. UK Biobank (http://www.ukbiobank.ac.uk) Research Ethics Committee (REC) approval number is 11/NW/0382. Our reference number approved by UK Biobank is 14575.