"Keaping" a lid on lung cancer: the Keap1-Nrf2 pathway
Sarah A Best, Kate D Sutherland
CELL CYCLE | TAYLOR & FRANCIS INC | Published : 2018
Lung cancer remains one of the world's deadliest cancers, with effective targeted treatment options available for only a small subset of patients. The rapid expansion of cancer genomics in recent years has provided insight into the genetic landscape of all major lung cancer subtypes and led to new discoveries on the heterogeneous biology underlying lung tumorigenesis. Interestingly, these studies have revealed a high frequency of alterations in the Kelch-like ECG-associated protein 1 (KEAP1)-Nuclear factor erythoid-2-related factor 2 (NRF2) stress response pathway, for which no targeted treatments are currently available. In this review, we describe the molecular mechanisms underlying NRF2 p..View full abstract
Awarded by National Health and Medical Research Council
Awarded by Victorian Cancer Agency
This work was supported by the National Health and Medical Research Council [APP1138275];Victorian Cancer Agency [ECSG16001].