Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection
Hillary A Vanderen, Kathleen Wragg, Fernanda Ana-Sosa-Batiz, Anne B Kristensen, Sinthujan Jegaskanda, Adam K Wheatley, Deborah Wentworth, Bruce D Wines, P Mark Hogarth, Steve Rockman, Stephen J Kent
JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2018
Background: New treatments for severe influenza are needed. Passive transfer of influenza-specific hyperimmune pooled immunoglobulin (Flu-IVIG) boosts neutralizing antibody responses to past strains in influenza-infected subjects. The effect of Flu-IVIG on antibodies with Fc-mediated functions, which may target diverse influenza strains, is unclear. Methods: We studied the capacity of Flu-IVIG, relative to standard IVIG, to bind to Fcγ receptors and mediate antibody-dependent cellular cytotoxicity in vitro. The effect of Flu-IVIG infusion, compared to placebo infusion, was examined in serial plasma samples from 24 subjects with confirmed influenza infection in the INSIGHT FLU005 pilot study...View full abstract
Awarded by Australian National Health and Medical Research Council
Awarded by NIAID Division of Clinical Research through University of Minnesota
This work was supported by the Australian National Health and Medical Research Council (award number 1052979 to S. J. K.) and the NIAID Intramural Research Program and the NIAID Division of Clinical Research, through a contract with the University of Minnesota (Leidos prime contract HHSN261200800001E).