Book Chapter

The international mismatch repair consortium

MA Jenkins, JC Reece, AK Win

Hereditary Colorectal Cancer: Genetic Basis and Clinical Implications | Springer International Publishing | Published : 2018


The International Mismatch Repair Consortium (IMRC) is a collaboration of clinicians and scientists who have agreed to pool and analyse data on Lynch syndrome, a genetic predisposition to cancer caused by germline mutations in DNA mismatch repair genes or EPCAM deletion, with the rationale that research on this hereditary syndrome will benefit from large datasets from many countries. As of October 2017, the IMRC includes approximately 273 members from 122 centres/clinics in 29 countries throughout Africa, Asia, Australasia, Europe, and North and South America, who are involved in research or treatment of people with Lynch syndrome and their families. To date, there are six research projects ..

View full abstract