Journal article
Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination
MMC Lam, KL Wyres, S Duchêne, RR Wick, LM Judd, YH Gan, CH Hoh, S Archuleta, JS Molton, S Kalimuddin, TH Koh, V Passet, S Brisse, KE Holt
Nature Communications | NATURE PORTFOLIO | Published : 2018
Open access
Abstract
Severe liver abscess infections caused by hypervirulent clonal-group CG23 Klebsiella pneumoniae have been increasingly reported since the mid-1980s. Strains typically possess several virulence factors including an integrative, conjugative element ICEKp encoding the siderophore yersiniabactin and genotoxin colibactin. Here we investigate CG23's evolutionary history, showing several deep-branching sublineages associated with distinct ICEKp acquisitions. Over 80% of liver abscess isolates belong to sublineage CG23-I, which emerged in ∼1928 following acquisition of ICEKp10 (encoding yersiniabactin and colibactin), and then disseminated globally within the human population. CG23-I's distinguishin..
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Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
We thank Jonathan Cotrupi for microbiological analysis of horse strains from France, Ulises Garza-Ramos and Alexis Criscuolo for help in genomic analyses, and Carla Rodrigues for assistance with Nanopore sequencing of strain SB4816. We also thank the team of the curators of the Institut Pasteur MLST system (Paris, France) for importing novel alleles, profiles and/or isolates at http://bigsdb.pasteur.fr. This work was supported by the NHMRC of Australia (fellowship #1061409 to KEH), National University of Singapore (grant number NUHSRO/2014/068/AF-New Idea/03 to Y.H.G.), and the Bill and Melinda Gates Foundation, Seattle.