Journal article

Infection-acquired versus vaccine-acquired immunity in an SIRWS model

Tiffany Leung, Patricia T Campbell, Barry D Hughes, Federico Frascoli, James M McCaw

INFECTIOUS DISEASE MODELLING | KEAI PUBLISHING LTD | Published : 2018

Abstract

In some disease systems, the process of waning immunity can be subtle, involving a complex relationship between the duration of immunity-acquired either through natural infection or vaccination-and subsequent boosting of immunity through asymptomatic re-exposure. We present and analyse a model of infectious disease transmission where primary and secondary infections are distinguished to examine the interplay between infection and immunity. Additionally we allow the duration of infection-acquired immunity to differ from that of vaccine-acquired immunity to explore the impact on long-term disease patterns and prevalence of infection in the presence of immune boosting. Our model demonstrates th..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

Tiffany Leung is supported by a Melbourne International Research Scholarship from the University of Melbourne and a National Health and Medical Research Council (NHMRC) funded Centre for Research Excellence in Infectious Diseases Modelling to Inform Public Health Policy (1078068).