Infection-acquired versus vaccine-acquired immunity in an SIRWS model
Tiffany Leung, Patricia T Campbell, Barry D Hughes, Federico Frascoli, James M McCaw
INFECTIOUS DISEASE MODELLING | KEAI PUBLISHING LTD | Published : 2018
In some disease systems, the process of waning immunity can be subtle, involving a complex relationship between the duration of immunity-acquired either through natural infection or vaccination-and subsequent boosting of immunity through asymptomatic re-exposure. We present and analyse a model of infectious disease transmission where primary and secondary infections are distinguished to examine the interplay between infection and immunity. Additionally we allow the duration of infection-acquired immunity to differ from that of vaccine-acquired immunity to explore the impact on long-term disease patterns and prevalence of infection in the presence of immune boosting. Our model demonstrates th..View full abstract
Related Projects (1)
Awarded by National Health and Medical Research Council (NHMRC)
Tiffany Leung is supported by a Melbourne International Research Scholarship from the University of Melbourne and a National Health and Medical Research Council (NHMRC) funded Centre for Research Excellence in Infectious Diseases Modelling to Inform Public Health Policy (1078068).