A Review of DNA Vaccines Against Influenza
Leo Yi Yang Lee, Leonard Izzard, Aeron C Hurt
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2018
The challenges of effective vaccination against influenza are gaining more mainstream attention, as recent influenza seasons have reported low efficacy in annual vaccination programs worldwide. Combined with the potential emergence of novel influenza viruses resulting in a pandemic, the need for effective alternatives to egg-produced conventional vaccines has been made increasingly clear. DNA vaccines against influenza have been in development since the 1990s, but the initial excitement over success in murine model trials has been tempered by comparatively poor performance in larger animal models. In the intervening years, much progress has been made to refine the DNA vaccine platform-the ra..View full abstract
Awarded by NHMRC development grant
The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health. LI and LL were supported by NHMRC development grant # 1112870.