Journal article
Time- and sex-dependent associations between prenatal alcohol exposure and placental global DNA methylation
YJ Loke, E Muggli, L Nguyen, J Ryan, R Saffery, EJ Elliott, J Halliday, JM Craig
Epigenomics | FUTURE MEDICINE LTD | Published : 2018
Abstract
Aim: Epigenetic changes, in particular in the placenta, may mediate the effects of prenatal alcohol exposure (PAE) on children's health. We examined the relationship between PAE patterns, based on dose and timing, and placental global DNA methylation. Methods: Using linear regression analysis, we examined the association between different PAE categories and placental global DNA methylation (n = 187), using the proxy measure of Alu-interspersed repeats. Results: Following adjustment for important covariates, we found no evidence of an association between PAE and placental global DNA methylation overall. However, when stratifying by newborn sex, PAE throughout pregnancy was associated with hig..
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Awarded by McCusker Charitable Foundation
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council Grant #1011070; senior research fellowship #1021252 (J Halliday) and #1045161 (R Saffery), and practitioner fellowship #1021480 (E Elliott) and the Victorian State Government's Operational Infrastructure Support Program. The study has also received funding from the McCusker Charitable Trust to assist with the biospecimen collection at birth. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.