Journal article
Identification of microRNA Biomarkers of Response to Neoadjuvant Chemoradiotherapy in Esophageal Adenocarcinoma Using Next Generation Sequencing
K Chiam, GC Mayne, DI Watson, RJ Woodman, TF Bright, MZ Michael, CS Karapetis, T Irvine, WA Phillips, R Hummel, T Wang, LK Pimlott, S Marri, DSJ Astill, AR Ruszkiewicz, SK Thompson, DJ Hussey
Annals of Surgical Oncology | SPRINGER | Published : 2018
Abstract
Background: Clinical trials report improved overall survival following neoadjuvant chemoradiotherapy in patients undergoing surgery for esophageal adenocarcinoma, with a 10–15% survival improvement. MicroRNAs (miRNAs) are small noncoding RNAs that are known to direct the behavior of cancers, including response to treatment. We investigated the ability of miRNAs to predict outcomes after neoadjuvant chemoradiotherapy. Methods: Endoscopic biopsies from esophageal adenocarcinomas were obtained before neoadjuvant chemoradiotherapy and esophagectomy. miRNA levels were measured in the biopsies using next generation sequencing and compared with pathological response in the surgical resection, and s..
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Awarded by Australian Cancer Research Foundation
Funding Acknowledgements
The authors thank Peter Devitt for assistance with sample identification, and members of the ACRF Cancer Genomics Facility including Joel Geoghegan, David Lawrence, Andreas Schreiber, and Anna Tsykin. Funding for this study was from NHMRC Project Grant APP595964, and a project grant awarded by Tour de Cure Australia.