Dynamic interplay of innate and adaptive immunity during sterile retinal inflammation: Insights from the transcriptome
Riccardo Natoli, Elizabeth Mason, Haihan Jiao, Aaron Chuah, Hardip Patel, Nilisha Fernando, Krisztina Valter, Christine Wells, Jan Provis, Matt Rutar
Frontiers in Immunology | Frontiers Media | Published : 2018
The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined network of sterile inflammatory responses. The delineation of innate and adaptive immune milieu amongst the broad leukocyte infiltrate, and the gene networks which construct these responses, are poorly described in the eye. Using photo-oxidative damage in a rodent model of subretinal inflammation, we employed a novel RNA-sequencing framework to map the global gene network signature of retinal leukocytes. This revealed a previously uncharted interplay of adaptive immunity during subretinal inflammation, including prolonged enrichment of myeloid and lymphocyte migrati..View full abstract
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We would like to thank the members of the ANU Bioinformatics Consultancy Unit, JCSMR, for their help in the analysis of the RNAseq data, as well as the funding agency Retina Australia for supporting this work.