Journal article

Chronic excess fluoride uptake contributes to degenerative joint disease (DJD): Evidence from six marsupial species

Clare Death, Graeme Coulson, Uwe Kierdorf, Horst Kierdorf, Richard Ploeg, Simon Firestone, Ian Dohoo, Jasmin Hufschmid

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2018

Abstract

One of the manifestations of chronic fluoride toxicosis in mammals is skeletal fluorosis, which can include lesions of degenerative joint disease (DJD). Although DJD lesions have been less commonly studied than bone or dental lesions in relation to the pathology and epidemiology of fluoride toxicosis, there have been multiple independent studies in various species that have concluded that there appears to be an effect. The mechanisms by which fluoride affects the joints are not clear, but our data provide evidence that chronic excess dietary fluoride intake contributes to DJD. Our study is the first to specifically address the association between fluoride exposure and DJD in multiple species..

View full abstract

Grants

Funding Acknowledgements

Clare Death was supported by an Australian Postgraduate Award Industry Scholarship in collaboration with Portland Aluminium, and the Holsworth Wildlife Endowment Fund. The funders are supportive of publication but had no role in study design or preparation of the manuscript.