Journal article
Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation
SNA Roesley, JE La Marca, AJ Deans, L Mckenzie, R Suryadinata, P Burke, M Portela, H Wang, O Bernard, B Sarcevic, HE Richardson
Cell Cycle | TAYLOR & FRANCIS INC | Published : 2018
Abstract
The SWI/SNF ATP-dependent chromatin-remodeling complex is an important evolutionarily conserved regulator of cell cycle progression. It associates with the Retinoblastoma (pRb)/HDAC/E2F/DP transcription complex to modulate cell cycle-dependent gene expression. The key catalytic component of the SWI/SNF complex in mammals is the ATPase subunit, Brahma (BRM) or BRG1. BRG1 was previously shown to be phosphorylated by the G1-S phase cell cycle regulatory kinase Cyclin E/CDK2 in vitro, which was associated with the bypass of G1 arrest conferred by BRG1 expression. However, it is unknown whether direct Cyclin E/CDK2-mediated phosphorylation of BRM/BRG1 is important for G1-S phase cell cycle progre..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work and BS was supported by an Australian Research Council (ARC) Discovery grant [DP0771366] and an National Health and Medical Research Council (NHMRC) Project grant [APP1011320] to BS and HER, and by funds from St Vincent's Institute of Medical Research, the Peter MacCallum Cancer Centre and La Trobe University. SNAR was supported by Melbourne International Fee Remission and Melbourne International Research Scholarships from the University of Melbourne. JELM was supported by an ARC Discovery grant to HER [DP 170102549]. AJD is a Victorian Cancer Agency fellow. Support was provided by the Victorian Government's OIS Program. LM, PB and RS were supported by the ARC Discovery grant [DP0771366] and/or the NHMRC Project grant [APP1011320]. MP was supported by a Cancer Council Victoria grant to HER [APP1041817]. HW was supported by Singapore National Medical Research Council [NMRC/CBRG/0082/2015]. HER was supported by an National Health and Medical Research Council (NHMRC) Fellowship level B [APP1020056], and funds from the La Trobe Institute of Molecular Science and La Trobe University.