Journal article

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M Vespa, Vikesh Shrestha, Nicholas Abend, Denes Agoston, Alicia Au, Michael J Bell, Thomas P Bleck, Manuel Buitrago Blanco, Jan Claassen, Ramon Diaz-Arrastia, Dominique Duncan, Ben Ellingson, Brandon Foreman, Emily J Gilmore, Lawrence Hirsch, Martin Hunn, Alaa Kamnaksh, David McArthur, Andrew Morokoff, Terrence O'Brien Show all

NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

Abstract

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patien..

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