The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M Vespa; Vikesh Shrestha; Nicholas Abend; Denes Agoston; Alicia Au; Michael J Bell; Thomas P Bleck; Manuel Buitrago Blanco; Jan Claassen; Ramon Diaz-Arrastia; Dominique Duncan; Ben Ellingson; Brandon Foreman; Emily J Gilmore; Lawrence Hirsch; Martin Hunn; Alaa Kamnaksh; David McArthur; Andrew Morokoff; Terrence O'Brien; Kristine O'Phelan; Courtney L Robertson; Eric Rosenthal; Richard Staba; Arthur Toga; Frederick A Willyerd; Lara Zimmermann; Elisa Yam; Susana Martinez; Courtney Real; Jerome Engel; Agoston Denes; Au Alicia; Bell J Michael; Bleck P Thomas; Branch Craig; Buitrago Blanco Manuel; Bullock Ross; Burrows T Brian; Claassen Jan; Clarke Robert; Cloyd James; Coles Lisa; Crawford Karen; Diaz-Arrastia Ramon; Duncan Dominique; Ellingson Benjamin; Engel Jerome; Foreman Brandon; Galanopoulou Aristea; Gilmore Emily; Grohn Olli; Harris Neil; Hartings Jed; Lawrence Hirsch; Hunn Martin; Jette Nathalie; Johnston Leigh; Jones Nigel; Kanner Andres; McArthur David; Monti Martin; Morokoff Andrew; Moshe Solomon; Mowrey Wenzhue; O'Brien Terence; O'Phelan Kristine; Pitkanen Asla; Raman Rema; Robertson Courtney; Rosenthal Eric; Shultz Sandy; Snutch Terrance; Staba Richard; Toga Arthur; Van Horn Jack; Vespa Paul; Willyerd Frederick; Zimmermann Lara

Journal article

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M Vespa, Vikesh Shrestha, Nicholas Abend, Denes Agoston, Alicia Au, Michael J Bell, Thomas P Bleck, Manuel Buitrago Blanco, Jan Claassen, Ramon Diaz-Arrastia, Dominique Duncan, Ben Ellingson, Brandon Foreman, Emily J Gilmore, Lawrence Hirsch, Martin Hunn, Alaa Kamnaksh, David McArthur, Andrew Morokoff, Terrence O'Brien Show all

NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

DOI: 10.1016/j.nbd.2018.07.025

Abstract

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patien..

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