The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

PM Vespa; V Shrestha; N Abend; D Agoston; A Au; MJ Bell; TP Bleck; MB Blanco; J Claassen; R Diaz-Arrastia; D Duncan; B Ellingson; B Foreman; EJ Gilmore; L Hirsch; M Hunn; A Kamnaksh; D McArthur; A Morokoff; T O'Brien; K O'Phelan; CL Robertson; E Rosenthal; R Staba; A Toga; FA Willyerd; L Zimmermann; E Yam; S Martinez; C Real; J Engel; P Bleck Thomas; C Branch; M Buitrago Blanco; R Bullock; BT Burrows; R Clarke; J Cloyd; L Coles; K Crawford; B Ellingson; A Galanopoulou; O Grohn; N Harris; J Hartings; H Lawrence; N Jette; L Johnston; N Jones; A Kanner; M Monti; S Moshe; W Mowrey; A Pitkanen; R Raman; C Robertson; S Shultz; T Snutch; J Van Horn; P Vespa

Journal article

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

PM Vespa, V Shrestha, N Abend, D Agoston, A Au, MJ Bell, TP Bleck, MB Blanco, J Claassen, R Diaz-Arrastia, D Duncan, B Ellingson, B Foreman, EJ Gilmore, L Hirsch, M Hunn, A Kamnaksh, D McArthur, A Morokoff, T O'Brien Show all

Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

DOI: 10.1016/j.nbd.2018.07.025

Abstract

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patien..

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