In Vivo Impedance Characterization of Cortical Recording Electrodes Shows Dependence on Electrode Location and Size

Sam E John; Nicholas V Apollo; Nicholas L Opie; Gil S Rind; Stephen M Ronayne; Clive N May; Thomas J Oxley; David B Grayden

Journal article

In Vivo Impedance Characterization of Cortical Recording Electrodes Shows Dependence on Electrode Location and Size

Sam E John, Nicholas V Apollo, Nicholas L Opie, Gil S Rind, Stephen M Ronayne, Clive N May, Thomas J Oxley, David B Grayden

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Published : 2019

DOI: 10.1109/TBME.2018.2854623

Abstract

OBJECTIVE: Neural prostheses are improving the quality of life for those suffering from neurological impairments. Electrocorticography electrodes located in subdural, epidural, and intravascular positions show promise as long-term neural prostheses. However, chronic implantation affects the electrochemical environments of these arrays. METHODS: In the present work, the effect of electrode location on the electrochemical properties of the interface was compared. The impedances of the electrode arrays were measured using electrochemical impedance spectroscopy in vitro in saline and in vivo four-week postimplantation. RESULTS: There was not a significant effect of electrode location (subdural, ..

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University of Melbourne Researchers

Nicholas Opie Author Medicine - Royal Melbourne Hospital

Thomas Oxley Author Medicine - Royal Melbourne Hospital

Sam John Author Biomedical Engineering

Clive May Author Biochemistry and Pharmacology

Stephen Ronayne Author Medicine - Royal Melbourne Hospital

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Grants

Awarded by National Health and Medical Research Council of Australia Project

Awarded by U.S. Defence Advanced Research Projects Agency Microsystems Technology Office

Awarded by Office of Naval Research Global

Funding Acknowledgements

This work was supported in part by the National Health and Medical Research Council of Australia Project under Grant APP1062532, in part by the U.S. Defence Advanced Research Projects Agency Microsystems Technology Office under Contract N66001-12-1-4045, in part by the Office of Naval Research Global under Grant N62909-14-1-N020, in part by the Defence Health Foundation, Australia (Booster Grant), and in part by the Victorian Government's Operational Infrastructure Support Program.