Journal article
Differing Effects of Parathyroid Hormone, Alendronate, and Odanacatib on Bone Formation and on the Mineralization Process in Intracortical and Endocortical Bone of Ovariectomized Rabbits
C Vrahnas, PR Buenzli, TA Pearson, BL Pennypacker, MJ Tobin, KR Bambery, LT Duong, NA Sims
Calcified Tissue International | SPRINGER | Published : 2018
Abstract
Bone is formed by deposition of a collagen-containing matrix (osteoid) that hardens over time as mineral crystals accrue and are modified; this continues until bone remodeling renews that site. Pharmacological agents for osteoporosis differ in their effects on bone remodeling, and we hypothesized that they may differently modify bone mineral accrual. We, therefore, assessed newly formed bone in mature ovariectomized rabbits treated with the anti-resorptive bisphosphonate alendronate (ALN—100µ g/kg/2×/week), the anabolic parathyroid hormone (PTH (1–34)—15µ g/kg/5×/week), or the experimental anti-resorptive odanacatib (ODN 7.5 µM/day), which suppresses bone resorption without suppressing bone ..
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Awarded by Merck
Funding Acknowledgements
The authors gratefully acknowledge technical assistance from Christine Jun, advice on the KKT method from Alvin Acerbo and Lisa Miller at Brookhaven National Laboratories, and very helpful critique from T. John Martin. This work was funded by an investigator-initiated Grant from MSD (AU) (No. 53291) to NAS. NAS was funded by an NHMRC Senior Research Fellowship. sFTIRM was undertaken on the Infrared Microspectroscopy beamline at the Australian Synchrotron, part of ANSTO. St. Vincent's Institute receives funds from the Victorian Government's Operational Infrastructure Support Program.