Journal article

Associations between adrenarcheal hormones, amygdala functional connectivity and anxiety symptoms in children

Marjolein EA Barendse, Julian G Simmons, Michelle L Byrne, George Patton, Lisa Mundy, Craig A Olsson, Marc L Seal, Nicholas B Allen, Sarah Whittle



OBJECTIVE: The transition from childhood to adolescence is a vulnerable period for the development of anxiety symptoms. There is some evidence that hormonal changes occurring during adrenarche, an early pubertal phase, might play a role in this increased vulnerability. Little is known about underlying brain mechanisms. Given the role of the amygdala-based fear circuit in anxiety, the current study aimed to investigate whether children's adrenarcheal hormone levels were associated with functional connectivity of the amygdala while processing fearful facial expressions, and how this in turn related to anxiety symptoms. METHOD: Participants were 83 children (M age 9.53 years) who completed two ..

View full abstract


Awarded by Australian Research Council (ARC)

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The authors declare no competing financial interests. This work was supported by the Australian Research Council (ARC; DP120101402), and the National Health and Medical Research Council (NHMRC; Career Development Fellowship 1125504 to SW).