Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy: Combined Analysis of Two Randomized Controlled Studies
Peter Gibbs, Volker Heinemann, Navesh K Sharma, Julien Taieb, Jens Ricke, Marc Peeters, Michael Findlay, Bridget Robinson, Christopher Jackson, Andrew Strickland, Val Gebski, Mark Van Buskirk, Huaqing Zhao, Guy van Hazel
CLINICAL COLORECTAL CANCER | CIG MEDIA GROUP, LP | Published : 2018
BACKGROUND: The primary tumor side is emerging as a major prognostic factor for patients with metastatic colorectal cancer (mCRC). We examined the survival data from 2 randomized studies to determine whether the outcomes differ between patients with mCRC with right-sided primary (RSP) tumors and those with left-sided primary (LSP) tumors after selective internal radiation therapy (SIRT) plus mFOLFOX6 (folinic acid [leucovorin], 5-fluorouracil, oxaliplatin) chemotherapy, versus chemotherapy alone. PATIENTS AND METHODS: Separate and combined analyses were performed on the data from the SIRFLOX and FOXFIRE global trials, which compared chemotherapy plus SIRT with chemotherapy alone for patients..View full abstract
We thank all investigators in the SIRFLOX and FOXFIRE Global study groups, in particular, the principal investigators (listed in the Supplemental Appendix; available in the online version). We acknowledge the editorial assistance provided by ESP Bioscience (Crowthorne, UK) during the preparation of our report. This work was supported by Sirtex Medical, Ltd, which funded the editorial assistance for preparation of our article.