Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy: Combined Analysis of Two Randomized Controlled Studies

P Gibbs; V Heinemann; NK Sharma; J Taieb; J Ricke; M Peeters; M Findlay; B Robinson; C Jackson; A Strickland; V Gebski; M Van Buskirk; H Zhao; G van Hazel; M Brown; M Burge; G Cardaci; S Clarke; P Eliadis; T Ferguson; V Ganju; P James; C Karapetis; W Liauw; G Marx; M Matos; L Nott; N Pavlakis; A Powell; T Price; D Ransom; E Segelov; J Shannon; N Singhal; E Walpole; M Craninx; T Delaunoit; A Deleporte; M Ferrante; K Geboes; A Hendlisz; K Hendrickx; M De Man; E Monsaert; V Moons; M Polus; E Boucher; J Balosso; P Chevallier; S Louafi; M Pracht; C Rebischung; D Smith; E Terrebonne; HR Bruch; G Gehbauer; T Helmberger; YD Ko; H Kröning; F Lammert; A Nusch; S Pluntke; K Ridwelski; J Riera-Knorrenschild; H Riess; JR Riera; T Sauerbruch; K Scheidhauer; O Stötzer; K Tatsch; U Vehling-Kaiser; T Vogl; A Beny; R Geva; E Shacham-Shmueli; S Stemmer; T Tichler; I Wolf; B Angelelli; A Martoni; MPN Findlay; R Isaacs; A O'Donnell; D Perez; J Rodríguez; R Vera-Garcia; P Amin; D Bloomgarden; J Bui; J Carlisle; S Chai; YJ Chen; M Chuong; A Coveler; F Facchini; G Frenette; J Frick; M Garofalo; B George; M Gordon

Journal article

Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy: Combined Analysis of Two Randomized Controlled Studies

P Gibbs, V Heinemann, NK Sharma, J Taieb, J Ricke, M Peeters, M Findlay, B Robinson, C Jackson, A Strickland, V Gebski, M Van Buskirk, H Zhao, G van Hazel, M Brown, M Burge, G Cardaci, S Clarke, P Eliadis, T Ferguson Show all

Clinical Colorectal Cancer | CIG MEDIA GROUP, LP | Published : 2018

DOI: 10.1016/j.clcc.2018.06.001

Abstract

The primary tumor side is emerging as a prognostic factor for patients with liver metastatic colorectal cancer (mCRC). In a combined analysis of data from 2 randomized studies, the addition of selective internal radiation therapy to first-line chemotherapy in patients with mCRC was associated with statistically and clinically significant overall survival gains for patients with a right-sided primary tumor. Background: The primary tumor side is emerging as a major prognostic factor for patients with metastatic colorectal cancer (mCRC). We examined the survival data from 2 randomized studies to determine whether the outcomes differ between patients with mCRC with right-sided primary (RSP) tumo..

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University of Melbourne Researchers

Peter Gibbs Author

Grants

Funding Acknowledgements

We thank all investigators in the SIRFLOX and FOXFIRE Global study groups, in particular, the principal investigators (listed in the Supplemental Appendix; available in the online version). We acknowledge the editorial assistance provided by ESP Bioscience (Crowthorne, UK) during the preparation of our report. This work was supported by Sirtex Medical, Ltd, which funded the editorial assistance for preparation of our article.