Risk factors for incident heart failure with preserved or reduced ejection fraction, and valvular heart failure, in a community-based cohort
Fei Fei Gong, Michael Jelinek, Julian M Castro, Jennifer M Coller, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Rory Wolfe, Simon Stewart, Alice J Owen, Henry Krum, Christopher M Reid, David L Prior, Duncan J Campbell
OPEN HEART | BMJ PUBLISHING GROUP | Published : 2018
Background: The lack of effective therapies for heart failure with preserved ejection fraction (HFpEF) reflects an incomplete understanding of its pathogenesis. Design: We analysed baseline risk factors for incident HFpEF, heart failure with reduced ejection fraction (HFrEF) and valvular heart failure (VHF) in a community-based cohort. Methods: We recruited 2101 men and 1746 women ≥60 years of age with hypertension, diabetes, ischaemic heart disease (IHD), abnormal heart rhythm, cerebrovascular disease or renal impairment. Exclusion criteria were known heart failure, left ventricular ejection fraction mild in severity. Median follow-up was 5.6 (IQR 4.6-6.3) years. Results: Median time to hea..View full abstract
The SCREEN-HF study was initially funded by Bupa Australia, with subsequent support from the National Health and Medical Research Council (NHMRC) of Australia, the National Heart Foundation of Australia and the Diabetes Australia Research Trust. DJC and SS received senior research fellowships from the NHMRC, and MM and JMCo received scholarship support from the NHMRC. St Vincent's Institute of Medical Research is supported in part by the Victorian Government's Operational Infrastructure Support Program.