Journal article

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Mathijs A Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E Miller, Adil S al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara McIennan, Remco M Hoogenboezem, Francois G Kavelaars, Stefan Froehling, Marnie E Blewitt, Eric M Bindels, Warren S Alexander, Bob Lowenberg, Andrew W Roberts, Peter JM Valk, Ian J Majewski

Blood | AMER SOC HEMATOLOGY | Published : 2018

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Independent Research Institutes Infrastructure Support Scheme Grant


Awarded by CTMM


Awarded by NWO


Awarded by NHMRC


Awarded by National Institutes of Health, National Cancer Institute


Awarded by Starr Cancer Consortium


Awarded by LLS SCOR


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) (program grant 1113577 [W.S.A. and A.W.R.] and project grant 1145912 [I.J.M.]), an Independent Research Institutes Infrastructure Support Scheme Grant (9000220), a Victorian State Government Operational Infrastructure Support Grant, The Netherlands Organisation for Scientific Research (NWO), and the Center for Translational Molecular Medicine (CTMM). M.A.S. is supported by a grant from CTMM (GR03O-102) and a Rubicon fellowship from NWO (019.153LW.038). E.C. is supported by a PhD scholarship from the Leukaemia Foundation of Australia. A.S.a.H. is supported by a PhD scholarship from the Ministry of Health, Sultanate of Oman. M.E.B. is supported by the Bellberry-Viertel fellowship. W.S.A. and A.W.R. are supported by fellowships from NHMRC (1058344 and 1079560, respectively). I.J.M. is supported by the Victorian Cancer Agency. The authors wish to acknowledge the generous philanthropic support of the Felton Bequest, Malcolm Broomhead, and BHP Billiton.The results are based, in part, on data generated by the TCGA Research Network (http://cancergenome.nih.gov/) and the Epigenetic studies in Acute Myeloid Leukemia (phs001027), which was supported by National Institutes of Health, National Cancer Institute (K08CA169055) (F.E. Garrett-Bakelman), Starr Cancer Consortium I4-A442 (A. M. Melnick, R. Levine, and C. E. Mason), and LLS SCOR 7006-13 (A. M. Melnick). Sequencing data from WEHI-AML-1 and WEHI-AML-2 have been deposited at the European Genome Phenome Archive (EGA) (EGAS00001002581). The data are available for ethically approved research into hematological malignancy upon completion of a data transfer agreement. Sequencing data from EMC-AML-1 were sourced from the dbGaP under accession phs001027. Sequencing data from the Mbd4 knockout mice is available through the National Center for Biotechnology Information (NCBI) Short Read Archive (SRP126117). The code for reproducing figures is made available through GitHub (https://github.com/MathijsSanders/AML-RoaMeR).