Journal article
Hypersensitivity to sertraline in the absence of hippocampal 5-HT1AR and 5-HTT gene expression changes following paternal corticosterone treatment
A Rawat, J Guo, T Renoir, TY Pang, AJ Hannan
Environmental Epigenetics | OXFORD UNIV PRESS | Published : 2018
DOI: 10.1093/eep/dvy015
Abstract
The male germ line is capable of transmitting a legacy of stress exposure to the next generation of offspring. This transgenerational process manifests by altering offspring affective behaviours, cognition and metabolism. Paternal early life trauma causes hippocampal serotonergic dysregulation in male offspring. We previously showed a transgenerational modification to male offspring anxiety-like behaviours by treatment of adult male breeders with corticosterone (CORT) prior to mating. In the present study, we used offspring from our paternal CORT model and characterised offspring serotonergic function by examining their responses to the 5HT1AR agonist, 8-OH-DPAT, and the selective serotonin ..
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Funding Acknowledgements
A.J.H. is an NHMRC Principal Research Fellow. T.R. is an NHMRC Dementia Fellow. This research was supported by an NHMRC Project Grant to A.J.H. and T.Y.P., and the DHB Foundation, Equity Trustees (A.J.H.) This work received support from the Victorian government through the Operational Infrastructure Scheme. Author contributions: T.Y.P. and A.J.H. conceived the study, T.Y.P. designed the study, T.Y.P., A.R., J.G., and T.R. performed the experiments, acquired and analysed the data. T.Y. P., A.R., and T.R. wrote the manuscript. A.J.H. edited and approved the manuscript.