Journal article
Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry
TG Wilson, Y d'Udekem, DS Winlaw, RL Cordina, DS Celermajer, GR Wheaton, A Bullock, TL Gentles, RG Weintraub, RN Justo, LE Grigg, DJ Radford, W Hardikar, M Cheung, TM Cain, P Rao, SI Alexander, J Ayer, C Verrall, K Du Plessis Show all
International Journal of Cardiology | ELSEVIER IRELAND LTD | Published : 2018
Abstract
Background: Hepatic and renal dysfunction have been observed in survivors of the Fontan procedure, however their incidence and associated factors remain poorly defined. Methods: A total of 152 participants from a Registry of 1528 patients underwent abdominal ultrasound, transient elastography (FibroScan), serum fibrosis score (FibroTest), in vivo Tc-99m DTPA measurement of glomerular filtration rate (mGFR), and urine albumin-creatinine ratio (ACR). Results: Mean age and time since Fontan were 19.8 ± 9.3 and 14.1 ± 7.6 years, respectively. Features suggestive of hepatic fibrosis were observed on ultrasound in 87/143 (61%) and no patient was diagnosed with hepatocellular carcinoma. FibroScan m..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This project was supported by a grant from the National Health and Medical Research Council (NHMRC Project Grant 1047923). The authors acknowledge support provided to the Murdoch Children's Research Institute by the Victorian Government's Operational Infrastructure Support Program. Yves d'Udekem is a NHMRC Clinician Practitioner Fellow (1082186).