CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function
Esther Bandala-Sanchez, Naiara G Bediaga, Ethan D Goddard-Borger, Katrina Ngui, Gaetano Naselli, Natalie L Stone, Alana M Neale, Lesley A Pearce, Ahmad Wardak, Peter Czabotar, Thomas Haselhorst, Andrea Maggioni, Lauren A Hartley-Tassell, Timothy E Adams, Leonard C Harrison
Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2018
Awarded by Australian National Health and Medical Research Council (NHMRC) Program
Awarded by NHMRC
We thank Dr. Ajit Varki for helpful discussions. This work was supported by Australian National Health and Medical Research Council (NHMRC) Program Grant 1037321 and the Walter and Eliza Hall Institute Catalyst Fund. L.C.H. is the recipient of a NHMRC Senior Principal Research Fellowship 1080887. We acknowledge TrendBio for access to the automated, quantitative Western blot analysis instrument (WES) system. The work was made possible through Victorian State Government Operational Infrastructure Support and NHMRC Research Institute Infrastructure Support Scheme.