Journal article
Melanin-concentrating hormone and orexin systems in rat nucleus incertus: Dual innervation, bidirectional effects on neuron activity, and differential influences on arousal and feeding
A Sabetghadam, A Grabowiecka-Nowak, A Kania, A Gugula, E Blasiak, T Blasiak, S Ma, AL Gundlach, A Blasiak
Neuropharmacology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018
Abstract
The rat nucleus incertus (NI) contains GABA/peptide-projection neurons responsive to orexin (hypocretin)/orexin receptor-2 (OX 2 ) signalling. Melanin-concentrating hormone (MCH) and orexin neurons often innervate and influence common target areas. Therefore, we assessed the relationship between these hypothalamic peptidergic systems and rat NI, by investigating the presence of an MCH innervation and MCH receptor-1 (MCH 1 ) expression, and neurophysiological and behavioural effects of MCH c.f. orexin-A (OXA), within the NI. We identified lateral hypothalamus (LH), perifornical and sub-zona incerta MCH neurons that innervate NI, and characterised the rostrocaudal distribution of MCH-containin..
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Awarded by National Alliance for Research on Schizophrenia and Depression
Funding Acknowledgements
The research was supported by NHMRC, project grant 1067522 (ALG), a NARSAD Independent Investigator Award (ALG), a grant from the Dorothy Levien Foundation (ALG), a Polish Ministry of Science and Higher Education (MSHE, Poland 0020/DIA/2014/43) grant (AK); The National Science Centre (DEC-2012/05/D/NZ4/02984) (AB and ALG) and (2014/15/B/NZ4/04896) (TB and AB); and an EU-funded Exchange Program (FP7-PEOPLE-IRSES PIRSES-GA-2012-318997 NEUREN project) (AB, ALG). AS was supported by MIRS and MIFRS postgraduate training awards from The University of Melbourne. We acknowledge financial support from the Victorian State Government Infrastructure Program to The Florey Institute of Neuroscience and Mental Health.