Prostate specific membrane antigen: The role in salvage lymph node dissection and radio-ligand therapy

Abstract

INTRODUCTION: Prostate-specific membrane antigen (PSMA) is a receptor highly expressed on the membranes of prostate cancer (PCa) cells and provides a new opportunity for imaging and targeted therapy in metastatic prostate cancer. The use of radio-labelled peptides with high affinity for PSMA-receptor allows for localization of oligo-metastasis to guide salvage lymph node (LN) dissection, and effective delivery of radionuclide therapy to PCa cells. This review discusses the current statistics of PSMA-guided salvage lymph-node dissection. EVIDENCE ACQUISITION: A non-systematic literature search of the Medline, Embase, and Scopus databases was performed in December 2017 using medical subject he..