Journal article

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

Loic Lionnard, Pauline Duc, Margs S Brennan, Andrew J Kueh, Martin Pal, Francesca Guardia, Barbara Mojsa, Maria-Alessandra Damiano, Stephan Mora, Irena Lassot, Ramya Ravichandran, Claude Cochet, Abdel Aouacheria, Patrick Ryan Potts, Marco J Herold, Solange Desagher, Jerome Kucharczak

Cell Death & Differentiation | NATURE PUBLISHING GROUP | Published : 2019


Awarded by World Cancer Research

Awarded by French National Research Agency

Funding Acknowledgements

This work was supported by grants from La Ligue contre le Cancer, regional committees of Drome, Herault and Lozere (to J.K.) and Gard (to S.D.), the Centre National de la Recherche Scientifique (CNRS), Leukaemia Foundation Australia, and Cancer Council Victoria Venture Grant (to M.J.H.), World Cancer Research 15-0177 (to P.R.P.). L.L. was supported by the University of Montpellier, La Ligue Nationale contre le Cancer and by the Programme de mobilite scientifique from the embassy of France in Australia. J.K. was supported by the University of Lyon and was recipient of a delegation CNRS program. The authors thank the Protein Science Facility of the SFR Biosciences Lyon for their valuable expertize and technical assistance in mass spectrometry analysis and Aurelie CornutThibault for preparation of samples. The authors also thank the staff of Montpellier Genomic Collection platform for providing TRIM28 cDNA clones and the imaging facility MRI, member of the National Infrastructure France-BioImaging supported by the French National Research Agency (ANR-10-INBS-04, "Investments for the future") for Microscopy and Cytometry Analysis. The authors are grateful to Drs. Nathalie Bonnefoy, Veronique Baldin, Olivier Coux, Damien Gregoire, Florence Cammas, and Anne-Marie Marini for fruitful discussions and reagents, Gilles Salles (HCL, Lyon-Sud) for support during the early stages of this work, and John A. Hickman for critical reading of the manuscript.