Journal article

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Denzil Furtado, Mattias Bjornmalm, Scott Ayton, Ashley I Bush, Kristian Kempe, Frank Caruso

ADVANCED MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2018

Abstract

Therapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largely due to the blood-brain barrier (BBB), arguably the most tightly regulated interface in the human body, which routinely excludes most therapeutics. Advances in the engineering of nanomaterials and their application in biomedicine (i.e., nanomedicine) are enabling new strategies that have the potential to help improve our understanding and treatment of neurological diseases. Herein, the various mechanisms by which therapeutics can be delivered to the brain are examined and key challenges facing translation of this research from benchtop to bedside are highlighted...

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Grants

Awarded by Australian Research Council (ARC) under the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship


Awarded by NHMRC-ARC Dementia Research Development Fellowship


Awarded by NHMRC Fellowship


Awarded by NIH Research Project Grant


Awarded by H2020/European Union through a Marie Sklodowska-Curie Individual Fellowship


Funding Acknowledgements

This article is part of the Advanced Materials Hall of Fame article series, which recognizes the excellent contributions of leading researchers to the field of materials science. This research was supported by the Australian Research Council (ARC) under the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036) and the Yulgilbar Foundation and Melbourne Neuroscience Institution. F.C. and K.K. gratefully acknowledge the award of a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (F.C., APP1135806) and an NHMRC-ARC Dementia Research Development Fellowship (K.K., APP1109945). A.I.B. is supported by an NHMRC Fellowship (GNT1103703), Project Grant (GNT1123625), and Program Grant (GNT11326040), and an NIH Research Project Grant (1RF1AG054057-01). M.B. acknowledges support from H2020/European Union through a Marie Sklodowska-Curie Individual Fellowship (grant agreement no. 745676). The authors thank Alison E. Burke and Cassio Lynm for assistance with preparing figures.