Journal article

The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia

Donald M Arnold, Francois Lauzier, Martin Albert, David Williamson, Na Li, Ryan Zarychanski, Chip Doig, Lauralyn McIntyre, Andreas Freitag, Mark Crowther, Lois Saunders, France Clarke, Rinaldo Bellomo, Ismael Qushmaq, Renato D Lopes, Diane Heels-Ansdell, Kathryn Webert, Deborah Cook

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS | WILEY | Published : 2017

Abstract

Background: Platelet transfusions are commonly used to treat critically ill patients with thrombocytopenia. Whether platelet transfusions are associated with a reduction in the risk of major bleeding is unknown. Patients/Methods: Observational cohort study nested in a previous multicenter, randomized thromboprophylaxis trial in the intensive care unit (ICU). The objective was to evaluate the association between platelet transfusions and adjudicated major bleeding events. Platelet transfusion episodes were reviewed for timing of administration, product type, and dose. Major bleeding with and without platelet transfusions was adjusted for severity of thrombocytopenia, use of anti-platelet agen..

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