Journal article

Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial

Catherine A Cluver, Natalie J Hannan, Erika van Papendorp, Richard Hiscock, Sally Beard, Ben W Mol, Gerhard B Theron, David R Hall, Eric H Decloedt, Marietjie Stander, Kim T Adams, Megan Rensburg, Pawel Schubert, Susan P Walker, Stephen Tong

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | MOSBY-ELSEVIER | Published : 2018

Abstract

BACKGROUND: Preterm preeclampsia has a high rate of fetal death or disability. There is no treatment to slow the disease, except delivery. Preclinical studies have identified proton pump inhibitors as a possible treatment. OBJECTIVE: The purpose of this study was to examine whether esomeprazole could prolong pregnancy in women who have received a diagnosis of preterm preeclampsia. STUDY DESIGN: We performed a double-blind, randomized controlled trial at Tygerberg Hospital in South Africa. Women with preterm preeclampsia (gestational age 26 weeks+0 days to 31 weeks+6 days) were assigned randomly to 40-mg daily esomeprazole or placebo. The primary outcome was a prolongation of gestation of 5 d..

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Grants

Funding Acknowledgements

Supported by The Geoff and Helen Handbury Foundation, The Beischer Medical Foundation for Mothers and Babies, The Mercy Perinatal Foundation and The Kilvington Trust; the National Health and Medical Research Foundation of Australia provided salary support to S.T. and B.W.M.; the University of Melbourne provided a CR Roper Fellowship (salary support) to N.J.H.; C.A.C. received the Discovery Academic Fellowship and the South African Medical Association PhD Bursary.