Journal article

Longitudinal expression profiling of CD4 and CD8 cells in patients with active to quiescent giant cell arteritis

Elisabeth De Smit, Samuel W Lukowski, Lisa Anderson, Anne Senabouth, Kaisar Dauyey, Sharon Song, Bruce Wyse, Lawrie Wheeler, Christine Y Chen, Khoa Cao, Amy Wong Ten Yuen, Neil Shuey, Linda Clarke, Isabel Lopez Sanchez, Sandy SC Hung, Alice Pebay, David A Mackey, Matthew A Brown, Alex W Hewitt, Joseph E Powell

BMC MEDICAL GENOMICS | BMC | Published : 2018


BACKGROUND: Giant cell arteritis (GCA) is the most common form of vasculitis affecting elderly people. It is one of the few true ophthalmic emergencies but symptoms and signs are variable thereby making it a challenging disease to diagnose. A temporal artery biopsy is the gold standard to confirm GCA, but there are currently no specific biochemical markers to aid diagnosis. We aimed to identify a less invasive method to confirm the diagnosis of GCA, as well as to ascertain clinically relevant predictive biomarkers by studying the transcriptome of purified peripheral CD4+ and CD8+ T lymphocytes in patients with GCA. METHODS: We recruited 16 patients with histological evidence of GCA at the Ro..

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Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by NHMRC Practitioner Fellowship

Awarded by NHMRC Career Development Fellowship an Australian Research Council Future Fellowship

Funding Acknowledgements

This work was supported by funding from Arthritis Australia, the Ophthalmic Research Institute of Australia, and an Australian National Health and Medical Research Council (NHMRC) grant (1083405), an NHMRC Practitioner Fellowship (AWH, 1103329), NHMRC Career Development Fellowship (JEP, 1107599) an Australian Research Council Future Fellowship (AP, FT140100047). CERA receives Operational Infrastructure Support from the Victorian Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.