Journal article

Growth changes after inhalant abuse and toluene exposure: A systematic review and meta-analysis of human and animal studies

R Crossin, AJ Lawrence, ZB Andrews, L Churilov, JR Duncan

HUMAN & EXPERIMENTAL TOXICOLOGY | SAGE PUBLICATIONS LTD | Published : 2019

Abstract

Inhalant abuse is a significant public health issue, particularly for adolescents, the predominant group of inhalant users. Adolescence is a critical growth period, and inhalant abuse has been associated with growth impairments, including reduced body weight and height. However, the extent to which inhalant abuse affects growth remains unquantified, and potential moderators remain unknown. To address this knowledge gap, a systematic review and meta-analysis of clinical human and preclinical animal studies utilizing toluene exposure (the primary solvent in abused products) was conducted. Five-hundred and sixty-nine studies were screened; 31 met inclusion criteria, yielding 64 toluene-control ..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

The author(s) disclosed receipt of following financial support for the research, authorship and/or publication of this article: This research was supported by the Australian National Health and Medical Research Council (NHMRC) (940835), of which AJL is a Principal Research Fellow (1116930) and ZBA is a Career Development Fellow (1084344) and the Victorian Government's Operational Infrastructure Support Scheme. RC is funded by a federal RTP scholarship. Funding bodies had no involvement in the design, analysis and decision to publish.