Journal article
FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants
R Grinter, ID Hay, J Song, J Wang, D Teng, V Dhanesakaran, JJ Wilksch, MR Davies, D Littler, SA Beckham, IR Henderson, RA Strugnell, G Dougan, T Lithgow
Plos Biology | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
Iron is essential for life. Accessing iron from the environment can be a limiting factor that determines success in a given environmental niche. For bacteria, access of chelated iron from the environment is often mediated by TonB-dependent transporters (TBDTs), which are β-barrel proteins that form sophisticated channels in the outer membrane. Reports of iron-bearing proteins being used as a source of iron indicate specific protein import reactions across the bacterial outer membrane. The molecular mechanism by which a folded protein can be imported in this way had remained mysterious, as did the evolutionary process that could lead to such a protein import pathway. How does the bacterium ev..
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Grants
Awarded by Wellcome Trust
Funding Acknowledgements
Australian Research Council (grant number FL130100038). Awarded to TL. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. National Health & Medical Research Council (grant number 1092262). Awarded to TL, RAS, GD. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Wellcome Trust (grant number 106077/Z/14/Z). Sir Henry Wellcome Fellowship awarded to RG. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.