Evaluation of self-collected vaginal specimens for the detection of high-risk human papillomavirus infection and the prediction of high-grade cervical intraepithelial lesions in a high-burden, low-resource setting
PJ Toliman, JM Kaldor, SG Badman, S Phillips, G Tan, JML Brotherton, M Saville, AJ Vallely, SN Tabrizi
CLINICAL MICROBIOLOGY AND INFECTION | ELSEVIER SCI LTD | Published : 2019
OBJECTIVES: To compare the performance of self-collected vaginal (V) specimens with clinician-collected cervical (C) specimens for detection of high-risk human papillomavirus (hrHPV) and cervical disease using the Cepheid Xpert HPV, Roche Cobas 4800 HPV and Hologic Aptima HPV assays. METHODS: Women aged 30-59 years (n = 1005) were recruited at two clinics in Papua New Guinea, and they provided specimens for testing at point-of-care using the Xpert HPV Test, and for subsequent testing using the Cobas HPV (n = 981) and Aptima HPV (n = 983) assays. Liquid-based cytology was performed on C specimens to predict underlying high-grade squamous intraepithelial lesions (HSIL). V specimen results of e..View full abstract
This work was funded through the National Health and Medical Research Council of Australia (NHMRC) and the Papua New Guinea Institute of Medical Research (PNGIMR) Internal Competitive Research Award Scheme (ICRAS). We acknowledge the generous core funding support provided to the PNGIMR by the Australian Aid Programme, Department of Foreign Affairs and Trade, Government of Australia. None of the funders or other organizations listed had any role in study design, data collection and interpretation, or the decision to submit the work for publication. JK is supported by an NHMRC Research Fellowship; AV is supported by an NHMRC Career Development Fellowship.