Journal article
Serine/threonine protein phosphatase 1 (PP1) controls growth and reproduction in Schistosoma japonicum
L Zhao, Z Lu, X He, MN Mughal, R Fang, Y Zhou, J Zhao, RB Gasser, CG Grevelding, Q Ye, M Hu
FASEB Journal | WILEY | Published : 2018
Abstract
Schistosomiasis is a human parasitic disease caused by flatworms of the genus Schistosoma. Adult female schistosomes produce numerous eggs that are responsible for the pathogenesis and transmission of the disease, and the maturation of female gonads depends on the permanent pairing of females and males. Signaling protein kinases have been proven to control female gonad differentiation after pairing; however, little is known about the roles of protein phosphatases in the developmental and reproductive biology of schistosomes. Here we explored 3 genes encoding catalytic subunits of serine/threonine protein phosphatase 1 (PP1c) that were structurally and evolutionarily conserved in Schistosoma ..
View full abstractGrants
Awarded by Stichting voor Fundamenteel Onderzoek der Materie
Funding Acknowledgements
The authors thank Prof. Kemei Peng (College of Veterinary Medicine, Huazhong Agricultural University) for technical assistance. They also thank Novogene Bioinformatics Technology Co. (Beijing, China) for RNA-seq library construction and bioinformatics analysis through a service contract. This work was supported by the National Key Basic Research Program (973 Program) of China (Grant 2015CB150300) and the Fundamental Research Funds for the Central Universities (Grant 2662017PY084; to M.H.), by the National Natural Science Foundation (Grant 31201897; to Q.Y.), by funds from Huazhong Agricultural University Scientific and Technology Self-Innovation Foundation (Program 2015RC005; to R.B.G.), and the LOEWE Center Novel Drug Targets against Poverty-Related and Neglected Tropical Infectious Diseases (DRUID) within the Hessian Excellence Initiative (Justus Liebig Universit; to C.G.G.). This work was also supported by the Natural Science Foundation of Hubei Province (Grant 2017CFA020; to M.H., R.F., Y.Z., and J.Z.). The authors declare no conflicts of interest.