Journal article
No detectable effect of Wolbachia wMel on the prevalence and abundance of the RNA virome of Drosophila melanogaster
Mang Shi, Vanessa L White, Timothy Schlub, John-Sebastian Eden, Ary A Hoffmann, Edward C Holmes
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | ROYAL SOC | Published : 2018
Abstract
Wolbachia is an endosymbiotic bacterium that can block viral infections in arthropods, generating interest in its potential to control the spread of mosquito-borne disease. Drosophila melanogaster is model organism for Wolbachia infection, and the wMel strain of Wolbachia can improve host survival following viral infection. However, it is unclear whether wMel induces anti-viral blocking against the broader native virome of D. melanogaster, or whether the major effect of Wolbachia is a reduction in viral abundance rather than viral clearance. We examined the effect of Wolbachia on viral abundance by comparing the total transcriptome of wMel-positive and wMel-negative D. melanogaster populatio..
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Grants
Awarded by NHMRC
Awarded by NIH
Awarded by ARC Australian Laureate Fellowship
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This study was supported by NHMRC Program grant 1037003 and NIH grant no. 1R01GM104325-01. E.C.H. is funded by an ARC Australian Laureate Fellowship (FL170100022) and A.A.H. by an NHMRC Research Fellowship (1118640).