GAL(3) receptor knockout mice exhibit an alcohol-preferring phenotype
Shannyn G Genders, Karlene J Scheller, Emily J Jaehne, Bradley J Turner, Andrew J Lawrence, Susanne M Brunner, Barbara Kofler, Maarten van den Buuse, Elvan Djouma
Addiction Biology | WILEY | Published : 2019
Galanin is a neuropeptide which mediates its effects via three G-protein coupled receptors (GAL1-3 ). Administration of a GAL3 antagonist reduces alcohol self-administration in animal models while allelic variation in the GAL3 gene has been associated with an increased risk of alcohol use disorders in diverse human populations. Based on the association of GAL3 with alcoholism, we sought to characterize drug-seeking behavior in GAL3 -deficient mice for the first time. In the two-bottle free choice paradigm, GAL3 -KO mice consistently showed a significantly increased preference for ethanol over water when compared to wildtype littermates. Furthermore, male GAL3 -KO mice displayed significantly..View full abstract
Awarded by NHMRC-ARC Dementia Research Leadership Fellowship
Awarded by Austrian Research Promotion Agency (FFG)
These studies were supported by the Research Focus Area, Understanding Disease at La Trobe University. SGG is supported by an Australian Government Research Training Program Scholarship. MvdB was supported by a Senior Research Fellowship from the National Health and Medical Research Council of Australia. BJT is supported by a NHMRC-ARC Dementia Research Leadership Fellowship (1137024) and the Stafford Fox Medical Research Foundation. The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. SMB was supported by the Austrian Research Promotion Agency (FFG, 822782/THERAPEP).